LI Yanlia, LYU Jingjinga, YANG Huizhenb
( a. Department of Oncology, b. Department of Endoscopy Center, the Second People′s Hospital of Jiaozuo,Jiaozuo 454000, China)
Abstract Objective To observe the application effect of continuous intravenous infusion of somatostatin in the palliative treatment of patients with tumors and intestinal obstruction. Methods 85 patients with tumors and intestinal obstruction were selected as the study subjects and randomly divided into two groups. 42 cases in the conventional group were treated with gastrointestinal decompression, while 43 cases in the experimental group were treated with somatostatin adjuvant therapy. The changes and recovery of gastrointestinal motility, gastric digestive function, inflammatory factors, and immune function were compare between two groups of patients. Results Under different treatment plans, the levels of gastrin ( GAS) and motilin ( MLT) in the experimental group were higher than those in the control group, showing a statistically significant difference ( P<0.05) ; the levels of gastric protease I ( PG I) and gastric protease Ⅱ( PGⅡ) in the experimental group were higher than those in the control group ( P<0.05) . The levels of C-reactive protein ( CRP ) , procalcitonin ( PCT) , and interleukin-6 ( IL-6) in the experimental group were lower than those in the control group ( P < 0.05) ; the levels of CD3+ , CD4+ , and CD4+/CD8+ in T lymphocytes in the experimental group were higher than those in the control group ( P<0.05) ; the recovery time of autonomous eating, first exhaust time, first defecation time, abdominal discomfort relief time, and hospitalization time in the experimental group were all shorter than those in the conventional group ( P < 0.05) . Conclusion Continuous intravenous infusion of somatostatin can improve the gastrointestinal motility and digestive function of patients with tumor complicated intestinal obstruction, and has a positive significance in alleviating inflammation, enhancing the body′ s immune system, and accelerating the recovery process.
Keywords: tumor combined with intestinal obstruction; somatostatin; gastrointestinal motility; digestive function; rehabilitation process
DOI:10.19296/j.cnki.1008-2409.2024-03-017
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