TANG Yajing^a, HUA Yimin^b, CAO Hang^a

( a. Department of Operating Room, b. Department of Rehabilitation, the

 First Hospital of Nanyang,Nanyang 473000,China)

Abstract Objective To observe the effect of acupuncture and moxibustion combined with sequential therapy of butylphthalide in patients with ischemic stroke. Methods 106 patients with ischemic stroke were selected as the research subjects and divided into the Western medicine group and traditional Chinese and Western medicine group using the number table method, with 53 cases in each group. The Western medicine group were treated with conventional western medicine and butylphthalide sequential therapy, while the traditional Chinese and Western medicine group were treated with Chinese medicine acupuncture and moxibustion. The inflammatory indicators, cerebral hemodynamic indicators, collateral circulation function, and neurological rehabilitation before and after treatment were compared between the two groups. Results After treatment, the nuclear factors-κB ( NF-κB ) , expression levels of Toll like receptor 4 ( TLR4) mRNA and Toll like receptor 2 ( TLR2) mRNA in the traditional Chinese and Western medicine groups were lower than those in the Western medicine group, and the differences were statistically significant ( P< 0.05) . The cerebral blood flow ( CBF) and cerebral blood volume ( CBV) in the traditional Chinese and Western medicine groups were higher than those in the Western medicine group ( P<0.05) . The mean transit time ( MTT) and maximum remaining functional time ( Tmax ) of blood flow in the traditional Chinese and Western medicine groups was lower than that in the Western medicine group ( P< 0.05) , as well as the calculated hypoperfusion index ( HIR ) were lower than those in the Western medicine group ( P < 0. 05) . The levels of neuronal enolase ( NSE) and central nervous system specific protein ( S100β) in the traditional Chinese and Western medicine groups were lower than those in the Western medicine group ( P<0.05) . Conclusion Acupuncture and moxibustion combined with sequential therapy of butylphthalide in traditional Chinese medicine can effectively reduce the inflammatory reaction in patients with ischemic stroke, and has positive significance in promoting their cerebral hemodynamics, collateral circulation function and rehabilitation of cerebral nerve function.

Keywords: ischemic stroke; acupuncture and moxibustion; sequential therapy with butylphthalide; inflammatory indicators; collateral circulation function

DOI:10.19296/j.cnki.1008-2409.2024-03-021

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