WANG Xiaoli¹, LI Mengyun², YE Cui¹

(1. Henan Provincal Veteran Cadres Rehabilitation Hospital , Zhengzhou 

450000, China;2. The First Affiliated Hospital of Nanyang Medical College, Nanyang 473000, China)

Abstract Objective To retrospectively analyze the effects of Cydiodine buccal tablets combined with minocycline hydrochloride ointment in the treatment of elderly chronic periodontitis ( CP) on periodontal status and pro-inflammatory factors of gingival crevicular fluid. Methods 106 elderly patients with chronic periodontitis were divided into two groups based on different treatment plans, with 53 cases in each group. Both groups were received routine periodontal treatment. On this basis, the control group were received treatment with Cydiodine buccal tablets, while the combination group were received treatment with Cydiodine buccal tablets and minocycline hydrochloride ointment. The effective rates of two treatment groups, including periodontal status indicators such as attachment loss ( AL) , bleeding index ( BI ) , plaque index ( PLI) , and periodontal probing depth ( PD) , as well as levels of pro-inflammatory factors such as thymic stromal lymphopoietin ( TSLP ) , human triggering receptor expressed on myeloid cells-1 ( TREM-1) , soluble intercellular adhesion molecular-1 ( sICAM-1) , and interleukin-6 ( IL-6) in gingival crevicular fluid, as well as adverse reactions were compared between the two groups. Results The total effective rate of the combined group was higher than that of the control group, and the difference was statistically significant ( P<0.05) . After 1 week and 4 weeks of treatment, CAL, BI, PLI and PD in the combined group were lower than those in the control group, and the difference was statistically significant ( P<0.05) . After 1 week and 4 weeks of treatment, TSLP, TREM-1, sICAM-1 and IL-6 in combination group were lower than those in control group, and the difference was statistically significant ( P < 0. 05) . There was no significant difference in the incidence of adverse reactions between the combined group and the control group ( P > 0. 05 ) . Conclusion Cydiodine buccal tablets combined with minocycline hydrochloride ointment are effective in the treatment of CP in the elderly, which can prevent the development of periodontal inflammation, improve periodontal function and have high safety.

Keywords: Cydiodine buccal tablets; minocycline hydrochloride ointment; chronic periodontitis; teath attachment loss

DOI:10.19296/j.cnki.1008-2409.2024-03-024

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